Prescription Drug Information
Prescription Drug
Abuse The non-medical use of
prescription drugs is a serious public health concern. Nonmedical use of
prescription drugs like opioids, central nervous system (CNS) depressants, and
stimulants can lead to abuse and addiction, characterized by compulsive drug
seeking and use.
In 1999, an estimated 4 million
people, about 2 percent of the population age 12 and older, were currently (use
in past month) using prescription drugs non-medically. Of these, 2.6 million
misused pain relievers, 1.3 million misused sedatives and tranquilizers, and
0.9 million misused stimulants. While prescription drug abuse affects many
Americans, some trends of particular concern can be seen among older adults,
adolescents, and women.
The misuse of prescribed
medications may be the most common form of drug abuse among the elderly. Older
people are prescribed medications about three times more frequently than the
general population, and have poorer compliance with directions for
use.
The National
Household Survey on Drug Abuse numbers indicate that the sharpest increases in
new users of prescription drugs for non-medical purposes occur in 12 to 17 and
18 to 25 year-olds. Among 12 to 14 year-olds, psychotherapeutics (e.g., pain
killers, tranquilizers, sedatives, and stimulants) were reported to be one of
two primary drugs used.
Overall, men and women have
roughly similar rates of nonmedical use of prescription drugs, with the
exception of 12 to 17 year olds. In this age group, young women are more likely
than young men to use psychotherapeutic drugs nonmedically. Also, among women
and men who use either a sedative, anti-anxiety drug, or hypnotic, women are
almost twice as likely to become addicted.
The Drug Abuse Warning Network,
which collects data on drug-related hospital emergency room episodes, reported
that mentions of hydrocodone as a cause for visiting an emergency room
increased 37 percent among all age groups from 1997 to 1999. Also, mentions of
clonazepam increased 102 percent since 1992.
Some Commonly Prescribed
Medications: Use and Consequences
Opioids
Oxycodone (OxyContin)
Propoxyphene (Darvon) Hydrocodone (Vicodin) Hydromorphone
(Dilaudid) Meperidine (Demerol) Diphenoxylate (Lomotil) |
|
CNS
Depressants Barbiturates
Mephobarbital (Mebaral)
Pentobarbital sodium (Nembutal) |
Benzodiazepines
Diazepam
(Valium) Chlordiazepoxide hydrochloride (Librium) Alprazolam (Xanax)
Triazolam (Halcion) Estazolam (ProSom) |
|
Stimulants
Dextroamphetamine (Dexedrine)
Methylphenidate (Ritalin) Sibutramine hydrochloride monohydrate
(Meridia) |
|
Generally
prescribed for
Postsurgical pain relief
Management of acute or chronic pain Relief of coughs and
diarrhea |
|
Generally
prescribed for
Anxiety Tension Panic
attacks Acute stress reactions Sleep disorders Anesthesia (at high
doses) |
|
Generally
prescribed for
Narcolepsy Attention-deficit
hyperactivity disorder (ADHD) Depression that does not respond to other
treatment Short-term treatment of obesity Asthma |
|
|
In the
body Opioids attach to opioid receptors in
the brain and spinal cord, blocking the transmission of pain messages to the
brain. |
In the
body CNS depressants slow brain activity
through actions on the GABA system and, therefore, produce a calming
effect. |
In the
body Stimulants enhance brain activity,
causing an increase in alertness, attention, and energy. |
Effects of
short-term use
Blocked pain
messages Drowsiness Constipation Depressed respiration (depending
on dose) |
|
Effects of
short-term use
| A "sleepy" and uncoordinated
feeling during the first few days, as the body becomes accustomed - tolerant -
to the effects, these feelings diminish. |
|
Effects of
short-term use
Elevated blood pressure
Increased heart rate Increased respiration Suppressed appetite
Sleep deprivation |
|
Effects of
long-term use Potential for tolerance,
physical dependence, withdrawal, and/or addiction
|
Effects of
long-term use Potential for tolerance,
physical dependence, withdrawal, and/or addiction
|
Effects of
long-term use Potential for
addiction |
Possible
negative effects Severe respiratory
depression or death following a large single dose |
Possible
negative effects Seizures following a
rebound in brain activity after reducing or discontinuing use |
Possible
negative effects
Dangerously high body
temperatures or an irregular heartbeat after taking high doses Cardiovascular failure or lethal seizures For some stimulants, hostility or feelings of paranoia after taking
high doses repeatedly over a short period of time
|
|
Should not be
used with Other substances that cause
CNS depression, including
Alcohol Antihistamines
Barbiturates Benzodiazepines General anesthetics |
|
Should not be
used with Other substances that cause
CNS depression, including
Alcohol Prescription opioid
pain medicines Some over-the-counter cold and allergy medications
|
|
Should not be
used with
Over-the-counter cold medicines
containing decongestants Antidepressants, unless supervised by a physician
Some asthma medications |
|
|